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Management of
Malignant Pericardial Effusion with
Instillation of Mitomycin C in Non-small
Cell Lung Cancer :Malignant
pericardial effusion resulting in cardiac
tamponade is a very serious clinical
situation. The immediate control of such
pericardial effusions is mandatory for
both survival and an improvement in the
performance status (PS) or the quality of
life of cancer patients. Tetracycline
hydrochloride, bleomycin sulfate,
cisplatin, carboplatin and mitomycin C
have been reported to be effective in
controlling malignant pericardial effusion
(1–8). These reports, however, have
dealt with heterogeneous neoplasms and
presented no evidence that the dose of
sclerosing agents was optimized. Thus, no
standard treatment for malignant
pericardial effusion has yet been
established. Therefore, updated approaches
and methods including the intrapericardial
instillation...See
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