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Cancer Risk

Obesity and Liver Cancer Risk
Jaapanese Journal of Clinical Oncology

Although chronic infection with hepatitis C virus (HCV) and hepatitis B virus (HBV) and alcohol consumption represent dominant risk factors for hepatocellular carcinoma, the most prevalent type (>90%) of primary liver cancer in Japan , Recent studies have highlighted non-alcoholic steatohepatitis (NASH) as an additional risk factor that occasionally leads to this malignancy via the development of idiopathic or cryptogenic cirrhosis . NASH is the severe inflammatory form of non-alcoholic fatty liver disease characterized by hepatic steatosis in the absence of excessive alcohol consumption, and its common co-morbid conditions include obesity and type 2 diabetes mellitus like other lifestyle-related diseases..In this context, overweight and obesity have been examined in causation of liver cancer, and accumulating evidence suggests that overweight or obese people with not only NASH...

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Molecular Oncology

Molecular Imaging of Prostate Cancer with PET
The Journal of Nuclear Medicine

Molecular imaging is paving the way for precision and personalized medicine. In view of the significant biologic and clinical heterogeneity of prostate cancer, molecular imaging is expected to play an important role in the evaluation of this prevalent disease. The natural history of prostate cancer spans from an indolent localized process to biochemical relapse after radical treatment with curative intent to a lethal castrate-resistant metastatic disease. The ongoing unraveling of the complex tumor biology of prostate cancer uniquely positions molecular imaging with PET to contribute significantly to every clinical phase of prostate cancer evaluation. The purpose of this article was to provide a concise review of the current state of affairs and potential future developments in the diagnostic utility of PET in prostate cancer....

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Oncology Around The World

Cancer Research

Genetic Ancestry and Risk of Mortality among U.S. Latinas with Breast Cancer
Cancer Research

Multiple studies have reported that Latina women in the United States are diagnosed with breast cancer at more advanced stages and have poorer survival than non-Latina White women. However, Latinas are a heterogeneous group with individuals having different proportions of European, Indigenous American, and African genetic ancestry. In this study, we evaluated the association between genetic ancestry and survival after breast cancer diagnosis among 899 Latina women from the San Francisco Bay area. Genetic ancestry was estimated from single-nucleotide polymorphisms from an Affymetrix 6.0 array and we used Cox proportional. ...

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Proteomics in epigenetics: new perspectives for cancer research
Briefings in Functional Genomics

The involvement of epigenetic processes in the origin and progression of cancer is now widely appreciated. Consequently, targeting the enzymatic machinery that controls the epigenetic regulation of the genome has emerged as an attractive new strategy for therapeutic intervention. The development of epigenetic drugs requires a detailed knowledge of the processes that govern chromatin regulation. Over the recent years, mass spectrometry (MS) has become an indispensable tool in epigenetics research. In this review, we will give an overview of the applications of MS-based proteomics in studying various aspects of chromatin....

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Cancer Economics

Palliative Care in Cancer

Trends in use and cost of initial cancer treatment in Ontario: a population-based descriptive study
CMAJ Open

The incidence of cancer in Canada has increased recently owing to population growth and aging. This increased incidence, in addition to the increased use of expensive new drugs and technologies to treat cancer, has led to a rise in cancer-related expenditures, which consume a growing share of limited health care budgets.....
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What Influences the Willingness of Community Physicians to Provide Palliative Care for Patients with Terminal Cancer? Evidence from a Nationwide Survey
Japanese Journal of Clinical Oncology

Since 1971, cancer has been the leading cause of death in Taiwan with the number of cancer deaths increasing every year . The hospice movement in Taiwan started in 1983 and the first palliative care unit was set up in 1990. In 2000, Taiwan became the first Asian country to have a legalized Natural Death Act, which provides medical personnel a legal basis upon which to a make medical decision in accordance with the will of patients. As of September 2008, there were 40 qualified palliative care units and 49 palliative home care services. ...
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Legal Issues in Cancer

Ethics and Cancer Care

Navigating legal constraints in clinical data warehousing: a case study in personalized medicine
Interface Focus

Personalized medicine relies in part upon comprehensive data on patient treatment and outcomes, both for analysis leading to improved models that provide the basis for enhanced treatment, and for direct use in clinical decision-making. A data warehouse is an information technology for combining and standardizing multiple databases. Data warehousing of clinical data is constrained by many legal and ethical considerations, owing to the sensitive nature of the data being stored. We describe an unconstrained clinical data warehousing architecture, some of the legal constraints that have led us to.....
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   Unrealistic optimism and the ethics of phase I cancer research
Journal of Medical Ethics

One of the most pressing ethical challenges facing phase I cancer research centres is the process of informed consent. Historically, most scholarship has been devoted to redressing therapeutic misconception, that is, the conflation of the nature and goals of research with those of therapy. While therapeutic misconception continues to be a major ethical concern, recent scholarship has begun to recognise that the informed consent process is more complex than merely a transfer of information and therefore cannot be evaluated only according to how well an individual understands such information. Other components of decision-making....
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